COCAINE AND WITHDRAWAL. 447
نویسندگان
چکیده
منابع مشابه
Withdrawal: Alcohol, Cocaine, Opioids and Other Drugs
Ethanol, illicit drugs, and prescription drugs used for nonmedical purposes are a significant medical as well as social problem. The 2005 National Survey on Drug Use and Health found that 22.7% of Americans, or 55 million individuals, were binge drinkers, which includes 16 million heavy drinkers (five or more drinks on the same occasion at least 5 different days in the prior 30 days) (1). Pain ...
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Continued usage of cocaine is determined by genetic, conditioned and homeostatic factors, while it is reinforced by drug-induced reward and the emotionally negative state of drug withdrawal, which includes anxiety. The molecular mechanisms of these long-term behavioral and physiological alterations have yet to be fully elucidated. Here we demonstrate that in zebrafish, a wide range of non-anest...
متن کاملDecreased presynaptic sensitivity to adenosine after cocaine withdrawal.
The nucleus accumbens (NAc) is a site mediating the rewarding properties of drugs of abuse, such as cocaine, amphetamine, opiates, nicotine, and alcohol (Wise and Bozarth, 1987; Koob, 1992; Samson andHarris, 1992; Woolverton and Johnson, 1992; Self and Nestler, 1995; Pontieri et al., 1996). Acute cocaine has been shown to decrease excitatory synaptic transmission mediated by the cortical affere...
متن کاملGender differences in zebrafish responses to cocaine withdrawal.
The acute responses to cocaine and its withdrawal contribute to cocaine dependence and potentiate relapse, with gender being one of the genetic factors affecting the outcome. Here we report that in both male and female zebrafish (Danio rerio, AB strain), an initial low-dose cocaine treatment (1.5 muM, immersion) does not acutely change their behavior. The cocaine withdrawal, however, is associa...
متن کاملCocaine withdrawal alters regulatory elements of dopamine neurons.
Cocaine is an extremely reinforcing drug that is readily selfadministered by both animals and humans. Although cocaine affects many transmitter systems in the brain, the best characterized are the dopaminergic neurons that originate in the midbrain and innervate areas in the forebrain. These include the nigrostriatal, mesolimbic, and mesocortical dopaminergic systems. Adequate characterization ...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1996
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199604001-00467